Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface |
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Authors: | Ye Shixin Discher Bohdana M Strzalka Joseph Xu Ting Wu Sophia P Noy Dror Kuzmenko Ivan Gog Thomas Therien Michael J Dutton P Leslie Blasie J Kent |
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Affiliation: | Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
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Abstract: | A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface. |
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