A Method of Study of Radioactive Tracer Kinetics |
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Authors: | Kajiya Fumihiko Kawagoe Kyoji Kodama Shinzo Hoki Noritake Inoue Michitoshi |
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Affiliation: | Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School; |
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Abstract: | This paper presents an approach to the problem of estimating the number of exponential functions and the pertinent parameters in the output of a radioactive tracer kinetic process. In particular, application of a criterion called an information theoretical criterion (AIC) for the estimation of the number of exponential functions is proposed; AIC was introduced by Akaike for the estimation of the order of linear dynamical systems and has been successfully applied for statistical model identification in a wide range of fields. Also, the maximum likelihood method was applied in order to evaluate AIC and to estimate decay constants and coefficients. |
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