| 丝素-羟丙基壳聚糖微球的结构和释药性能 |
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| 引用本文： | 来水利,王克玲,张敏,陈峰.丝素-羟丙基壳聚糖微球的结构和释药性能[J].精细化工,2010,27(2). |
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| 作者姓名： | 来水利 王克玲 张敏 陈峰 |
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| 作者单位： | 陕西科技大学,教育部轻化工助剂化学与技术重点实验室,陕西,西安,710021 |
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| 基金项目： | 陕西省咸阳市科技计划项目(XK06012-8)~~ |
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| 摘 要： | 以胰岛素为目标药物,以丝素(SF)和羟丙基壳聚糖(HPCS)为包药材料,复凝聚法制备SF-HPCS载药微球。采用红外光谱(FTIR)、扫描电镜(SEM)、X射线衍射(XRD)、热重分析(TGA)等对载药微球的结构、外部形貌及热性能等进行了表征。结果表明,所制备的载药微球表面密实,平均粒径22.4μm,呈正态分布;载药微球对胰岛素的包埋率达73.6%,大于HPCS载药微球(64.3%)及壳聚糖(CS)载药微球(57.1%);SF-HPCS载药微球在人工胃液中4h内累计释药率为21.3%,在人工肠液中24h内累计释药率达81.2%,48h累计释药率为92.2%,释放过程平稳、缓慢。
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| 关 键 词： | 丝素 羟丙基壳聚糖 载药微球 释药性能 医药原料 |
The Structure and the Release Performance of Silk Fibroin-hydroxypropyl Chitosan Microspheres |
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| LAI Shui-li,WANG Ke-ling,ZHANG Min,CHEN Feng.The Structure and the Release Performance of Silk Fibroin-hydroxypropyl Chitosan Microspheres[J].Fine Chemicals,2010,27(2). |
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| Authors: | LAI Shui-li WANG Ke-ling ZHANG Min CHEN Feng |
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| Affiliation: | Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry/a>;Ministry of Education/a>;Shaanxi University of Science & Technology/a>;Xi'an 710021/a>;Shaanxi/a>;China |
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| Abstract: | Insulin was used as the targeting drugs and silk protein and hydroxypropyl chitosan as the drugs package material,to prepare the SF-HPCS microspheres using the complex coacervation.Scanning electron microscopy(SEM)was applied to observe the appearance of microspheres.The infrared spectroscopy(FTIR),scanning electron microscopy(SEM),X-ray diffraction(XRD)and thermogravimetric analysis(TGA)were used to characterize the microspheres containing the drug structure,the external morphology and thermal properties.T... |
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| Keywords: | silk fibroin hydroxypropyl chitosan drug-loaded microspheres release performance drug materials |
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