| 水中"一锅"合成7,7-二甲基-4-(3-氯苯基)-5-氧代-3,4,5,6,7,8-六氢香豆素的洁净方法 |
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| 引用本文： | 靳通收,赵瑞巧,王爱卿,杜超. 水中"一锅"合成7,7-二甲基-4-(3-氯苯基)-5-氧代-3,4,5,6,7,8-六氢香豆素的洁净方法[J]. 化学试剂, 2006, 28(10): 621-622 |
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| 作者姓名： | 靳通收 赵瑞巧 王爱卿 杜超 |
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| 作者单位： | 河北大学,化学与环境科学学院,河北,保定,071002 |
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| 基金项目： | 国家自然科学基金资助项目(29872011)，教育部高等学校骨干教师资助项目，河北省自然科学基金资助项目(203107)。 |
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| 摘 要： | 研究了四丁基溴化铵(TBAB)催化下的水介质中,3-氯苯甲醛、丙二酸亚异丙酯和5,5-二甲基-1,3-环己二酮三组分缩合,一步合成系列7,7-二甲基-4-(3-氯苯基)-5-氧代-3,4,5,6,7,8-六氢香豆素。产物的结构经IR和1HNMR进行了表征确证。该方法具有反应条件温和、操作简便、环境友好的优点。
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| 关 键 词： | 3-氯苯甲醛 丙二酸亚异丙酯 5 5-二甲基-1 3-环己二酮 水介质 合成 |
| 文章编号： | 0258-3283（2006）10-0621-02 |
| 收稿时间： | 2006-01-26 |
| 修稿时间： | 2006-01-26 |
Clean one-pot synthesis of 4-(3-chlorophenyl)-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin in aqueous medium |
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| JIN Tong-shou,ZHAO Rui-qiao,WANG Ai-qing,DU Chao. Clean one-pot synthesis of 4-(3-chlorophenyl)-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin in aqueous medium[J]. Chemical Reagents, 2006, 28(10): 621-622 |
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| Authors: | JIN Tong-shou ZHAO Rui-qiao WANG Ai-qing DU Chao |
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| Affiliation: | College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China |
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| Abstract: | The 4-(3-chlorophenyl)-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin was synthesized from 3-chlorobenzaldehyde,5,5-dimethyl-1,3-cyclohexanedione and isopropylidene malonate catalyzed by tetrabutylammonium bromide in aqueous medium.The structures of the product was characterized by IR and 1HNMR .This method provided several advantages such as mild reaction conditions,simple work-up procedure and environment friendly.In addition,water was chosen as a green solvent. |
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| Keywords: | 3-chlorobenzaldehyde isopropylidene malonate 5 5-dimethyl-1 3-cyclohexanedione aqueous medium synthesis |
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