The NMDA receptor antagonist MK-801 elicits conditioned place preference in rats |
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Authors: | RT Layer FG Kaddis LJ Wallace |
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Affiliation: | Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210. |
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Abstract: | (+)-5-Methyl-10,11-dihydro-5H-dibenzoa,d]cyclohepten-5,10-imine maleate, (MK-801) a potent noncompetitive antagonist of central NMDA receptors, has been hypothesized to have rewarding properties indicative of abuse potential. To test this hypothesis, the effects of MK-801 on the acquisition of a conditioned place preference and on locomotor activity were assessed and compared with d-amphetamine. Both MK-801 (0.03 and 0.1 mg/kg, SC) and d-amphetamine (1.0 mg/kg, SC) administration resulted in the acquisition of a conditioned place preference. However, while both amphetamine and the higher dose of MK-801 produced a behavioral activation during the training period the lower dose of MK-801 did not. These results suggest that MK-801, at doses that produce behavioral activation and below, is rewarding and therefore may have abuse potential. |
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