| 玉米低聚肽降血压作用的实验研究 |
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| 引用本文： | 林峰,梁锐,王军波,李勇.玉米低聚肽降血压作用的实验研究[J].食品与发酵工业,2009(8). |
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| 作者姓名： | 林峰 梁锐 王军波 李勇 |
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| 作者单位： | 北京大学公共卫生学院营养与食品卫生系; |
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| 基金项目： | 国家十一五科技支撑项目(2006BAD27B01) |
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| 摘 要： | 为了研究玉米低聚肽的降血压作用,以原发性高血压大鼠为实验动物,分别灌胃给予不同剂量(0.45、1.35、4.05g/kg.bw)的玉米低聚肽,空白对照组灌胃给予相应剂量的蒸馏水,阳性对照组灌胃给予10mg/kg.bw卡托普利。连续灌胃8周后,各组大鼠体重、心脏/体重比、心率无明显变化(P>0.05)。低、中剂量组和卡托普利组的收缩压均显著低于空白对照组(P<0.05),低剂量组与卡托普利组的降压效果相当。高剂量组和卡托普利组的血清醛固酮浓度显著低于空白对照组(P<0.01)。实验结果表明,玉米低聚肽具有明显的降血压作用,这一结果将为进一步开发降血压药物和功能食品提供了科学依据。
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| 关 键 词： | 玉米低聚肽 降血压 原发性高血压大鼠 |
The Experimental Study on the Antihypertensive Effect of Corn Oligopeptides |
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| Lin Feng,Liang Rui,Wang Junbo,Li Yong.The Experimental Study on the Antihypertensive Effect of Corn Oligopeptides[J].Food and Fermentation Industries,2009(8). |
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| Authors: | Lin Feng Liang Rui Wang Junbo Li Yong |
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| Affiliation: | Lin Feng,Liang Rui,Wang Junbo,Li Yong(Department of Nutrition and Food Hygiene,School of Public Health,Peking University,Beijing 100191,China) |
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| Abstract: | To explore the antihypertensive effect of corn oligopeptides,the case group of SHR were fed with different dosage of corn oligopeptides(0.45,1.35,4.05 g/kg.bw)by gavage for 8 consecutive weeks,while the blank control group and the positive control group were treated with equal cubage of distilled water and 10 mg/kg.bw of captopril respectively.At the end of the experiment,there were no statistically significant differences in body weight,heart/body weight ratio,and heart rate.The blood pressure of SHR in th... |
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| Keywords: | corn oligopeptides antihypertensive effect SHR |
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