| 影响2-18F-2-脱氧-β-D-葡萄糖合成效率因素初探 |
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| 引用本文： | 张锦明,张书文,田嘉禾,宦定才,陈英茂. 影响2-18F-2-脱氧-β-D-葡萄糖合成效率因素初探[J]. 同位素, 2003, 16(1): 30-34 |
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| 作者姓名： | 张锦明 张书文 田嘉禾 宦定才 陈英茂 |
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| 作者单位： | 1. 中国人民解放军总医院核医学科,北京,100853
2. 中国人民解放军总医院药材处,北京,100853 |
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| 摘 要： | 以双管法合成2-^18F-2-脱氢-β-D-葡萄糖(^18F—FDG)为例,系统分析了影响^18F—FDG合成效率的各因索。结果表明,合成体系中的含水量是影响^18F—FDG合成效率的主要因索;不纯的回收Hz^18O也是合成效率下降的原因之一;前体的用量不低于15mg即可满足要求,缩短合成时间有利于提高合成的效率(End of Synthesis,EOS)。通过降低体系中水的含量,合成时间从55min缩短到44min,校正效率(End of Bombardment,EOB)从50％提高到65％。
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| 关 键 词： | 合成效率 2－^18F－2－脱氢－β－D－葡萄糖 双管法 含水量 校正效率 亲核反应 放化纯度 |
| 文章编号： | 1000-7512(2003)01-0030-05 |
| 修稿时间： | 2002-08-06 |
The Primary Result of Influence Factor on Synthesis Efficiency of 18F-FDG |
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| ZHANG Jing-min,ZHANG Shu-wen,TIAN Jia-he,HUAN Ding-cai,CHEN Ying-mao. The Primary Result of Influence Factor on Synthesis Efficiency of 18F-FDG[J]. Isotopes, 2003, 16(1): 30-34 |
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| Authors: | ZHANG Jing-min ZHANG Shu-wen TIAN Jia-he HUAN Ding-cai CHEN Ying-mao |
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| Abstract: | The influence factor on effiency of 18F-FDG is investigated with "2-pot"system to improve the yield of 18F-FDG. The synthesis effiency is leaded to low in evidence by water in synthesis system which it comes from K2. 2. 2 or acetonitrile of delivered tube. The lower impurity of recovery H218O also lead to low yield. The Triflate more than 15 mg can accord with operating requirement. The shortened synthesis time will benefit to EOS. The synthesis time shorten from 55 min to 44 min EOB can be increased from 50% to 65% by optimized synthesis time and controlled less water in synthesis. |
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| Keywords: | 18F-FDG synthesis effiency influence factor |
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