| 色满酮类化合物的合成及其抗炎活性研究 |
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| 引用本文： | 郑伟,孙光,孙宝佳,郅慧,胡春. 色满酮类化合物的合成及其抗炎活性研究[J]. 精细化工中间体, 2009, 39(1): 30-33 |
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| 作者姓名： | 郑伟 孙光 孙宝佳 郅慧 胡春 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 设计合成了4种色满酮类化合物，并利用熔点、红外光谱、核磁共振氢谱等手段确定了其结构。采用二甲苯致小鼠耳肿胀法，测定了该化合物的抗炎活性，实验结果表明在200mg／kg剂量下所合成的3个目标化合物6-[2-（4-吗啉基）乙氧基]色满酮、6-[（喹啉-2-基）甲氧基]色满酮、7-[2-（4-吗啉基）乙氧基]色满酮对二甲苯所致小鼠耳肿胀具有显著的抑制作用。
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| 关 键 词： | 药物化学 杂环 色满酮 衍生物 合成 抗炎 |
Study on Synthesis and Anti-inflammatory Activity of Chromanone Derivatives |
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| ZHENG Wei,SUN Guang,SUN Bao-jia,ZHI Hui,HU Chun. Study on Synthesis and Anti-inflammatory Activity of Chromanone Derivatives[J]. Fine Chemical Intermediates, 2009, 39(1): 30-33 |
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| Authors: | ZHENG Wei SUN Guang SUN Bao-jia ZHI Hui HU Chun |
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| Affiliation: | School of Pharmaceutical Engineering;Shenyang Pharmaceutical University;Shenyang 110016;China |
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| Abstract: | In order to study the structure-activity relationships of chromanone derivatives with anti-inflammatory activity,we have designed and synthesized some new chromanone derivatives and characterized with IR and 1H NMR.The anti-inflammatory activity was evaluated with xylene-induced mouse ear swelling model.Results showed that some of the target compounds such as 6-[2-(4-morpholinoethoxy)]chromanone,6-(2-quinolinomethoxy) chromanone,and 7-[2-(4-morpholinoethoxy)] chromanone showed potent anti-inflammatory at a ... |
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| Keywords: | heterocycle chromanone synthesis anti-inflammation |
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