| 2-脱氧-L-核糖的合成方法进展 |
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| 引用本文： | 邓达,卓超,陈友.2-脱氧-L-核糖的合成方法进展[J].精细化工中间体,2007,37(2):9-12. |
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| 作者姓名： | 邓达 卓超 陈友 |
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| 作者单位： | 华东理工大学,药学院,上海,200237;华东理工大学,药学院,上海,200237;华东理工大学,药学院,上海,200237 |
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| 摘 要： | 2-脱氧-L-核糖是合成L-核苷类抗病毒药物的重要中间体。笔者综述了2-脱氧-L-核糖的合成方法进展,重点介绍了以糖类及其衍生物为原料合成2-脱氧-L-核糖的方法。按照起始原料的不同,可分为:1)L-阿拉伯糖;2)D-木糖;3)D-半乳糖;4)L-抗坏血酸;5)D-葡萄糖酸-1,4-内酯。
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| 关 键 词： | 2-脱氧-L-核糖 L-阿拉伯糖 D-木糖 D-半乳糖 L-抗坏血酸 D-葡萄糖酸-1 4-内酯 |
| 文章编号： | 1009-9212（2007）02-0009-04 |
| 修稿时间： | 2006-10-18 |
Progress in Synthetic Methods of 2-Deoxy-L-ribose |
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| DENG Da,ZHUO Chao,CHEN You.Progress in Synthetic Methods of 2-Deoxy-L-ribose[J].Fine Chemical Intermediates,2007,37(2):9-12. |
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| Authors: | DENG Da ZHUO Chao CHEN You |
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| Affiliation: | School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | 2-Deoxy-L-ribose is the key intermediate in the synthesis of L-nucleosides. The various synthetic methods for the synthesis of 2-deoxy-L-ribose and their recent advances were reviewed,and synthetic methods were discussed in detail employing sugar or its derivatives as starting materials such as:1)L-arabinose;2)D-xylose;3)D-galactose;4)L-ascorbic acid;5)D-glucono-1,4-lactone. |
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| Keywords: | 2-deoxy-L-ribose L-arabinose D-xylose D-galactose L-ascorbic acid D-glucono-1 4-lactone |
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