Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism |
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Authors: | Randall Wood Theresa Lee Herman Gershon |
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Affiliation: | (1) Department of Biochemistry and Biophysics, Texas Agricultural Experiment Station, Texas A&M University System, 77843 College Station, Texas;(2) Boyce Thompson Institute for Plant Research, Cornell University, 14853 Ithaca, New York |
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Abstract: | Normal and hepatoma bearing rats were fed a low level of methyl 2-hexadecynoate in a low fat diet for one month. The effect
of the acetylenic acid on lipid metabolism as derived from mass analysis of lipid classes, fatty acids and positional monoene
isomers isolated from the major lipid classes of liver and hepatoma has been assessed. Methyl 2-hexadecynoate caused a 25%
decrease in body weight and the appearance of essential fatty acid deficiency symptoms within one week. Non-tumor-bearing
animals contained a seven-fold increase in all neutral lipid classes, except cholesterol, while host animals did not contain
fatty livers. The apparent protective effect of the host animal by the hepatoma also resulted in only marginal changes in
the fatty acid and positional monoene isomers from host liver and hepatoma lipids. In contrast to host liver and hepatoma,
methyl 2-hexadecynoate caused a massive accumulation of palmitate and hexadecenoates with a concomitant decrease in stearate
and octadecenoates in most of the lipid classes from non-tumor-bearing animals. These changes were accompanied by a shift
from the higher molecular weight triglycerides to lower molecular weights corresponding to carbon number 48. The high concentrations
of hexadecenoates consisted predominantly of the Δ9 isomer. Despite the high concentrations ofcis Δ9 hexadecenoate, precursor ofcis Δ11 octadecenoate (vaccenate), total vaccenate levels of the five major lipid classes were lower than control values. All
of these data strongly suggest that long-chain 2-ynoic acids inhibit elongation of saturated and monoene fatty acids. |
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