Evaluation of process parameter of an automated dip-coating |
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| Authors: | Catrin Strobel Anke Kadow-Romacker Tom Witascheck Gerhard Schmidmaier Britt Wildemann |
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| Affiliation: | 1. Department of Chemical Materials Engineering, The University of Auckland, Private Bag 92019, New Zealand;2. Light Metals Research Centre, The University of Auckland, Private Bag 92019, New Zealand;3. Institut fuer Werkstoffkunde (Materials Science), Leibniz Universität Hannover, An der Universitaet 2, 30823 Garbsen, Germany;1. DICATeA - Università degli Studi di Parma, Parco Area delle Scienze 181/A, 43124 Parma, Italy;2. DICeM - Università di Cassino e del Lazio Meridionale, Via G. Di Biasio 43, 03043 Cassino (FR), Italy;3. DICMA - Università di Roma “La Sapienza”, via Eudossiana 18, 00184 Rome, Italy;1. Department of Industrial and Information Engineering, Second University of Naples, Via Roma 29, 81031 Aversa, Italy;2. Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Via Vignolese 905, 41125 Modena, Italy |
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| Abstract: | Dip coating is a common technique for the optimization of metallic implants, whereas several steps during the procedure influence the coating. This study aims in the development of a coating apparatus and the evaluation of critical steps, such as mixing, immersion, retention and withdrawal velocity during the procedure. In addition the influence of the polymer solution viscosity, poly(d,l-lactide) dissolved in ethyl acetate, was analyzed. As a therapeutic drug, gentamicin was incorporated and the amount in the different coatings quantified. With increased withdrawal velocity and viscosity the thickness of the coating layer increased. This was accompanied by an increase in incorporated drug. The mixing, immersion and retention time had almost no effect. The viscosity of the polymer solution and the withdrawal velocity can therefore be used to modify bioactive coatings for optimized local drug loading. |
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