Novel,simple and reproducible method for preparation of composite hierarchal porous structure scaffolds |
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| Authors: | Seyed-Iman Roohani-Esfahani Zufu Lu Hala Zreiqat |
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| Affiliation: | 1. Department of Orthopedic Surgery, Center for Orthopedic Research, Columbia University, NY, USA;2. Mechanical Engineering, Kyung Hee University, Yongin, Korea;3. Department of Chemical Engineering, Kyungil University, Gyeongsan, Korea;1. Cellulose Sciences International, Madison, WI, United States;2. National Renewable Energy Laboratory, Golden, CO, United States;3. University of Wisconsin-Madison, Madison, WI, United States;1. USTHB, Faculté de Chimie BP 32, Bab Ezzouar, 16111 Alger, Algeria;2. ENSSMAL, BP 19 Bois des Cars, Campus Universitaire Dely Ibrahim, 16320 Alger, Algeria;3. Wacker-Chemie AG, Johannes-Hess-Str.24, D-84489 Burghausen, Germany;4. Adscientis, 1 rue Kastler, Wittelsheim, 68310, France;5. ENSISA-W, 11 rue Werner, 68093 Mulhouse Cedex, France |
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| Abstract: | Demand to develop a simple and adaptable method for preparation the hierarchical porous scaffolds for bone tissue regeneration is ever increasing. This study presents a novel and reproducible method for preparing the scaffolds with pores structure spanning from nano, micro to macro scale. A macroporous Sr-Hardystonite (Sr–Ca2ZnSi2O7, Sr–HT) scaffold with the average pore size of ~ 1200 μm and porosity of ~ 95% was prepared using polymer sponge method. The struts of the scaffold were coated with a viscous paste consisted of salt (NaCl) particles and polycaprolactone (PCL) to provide a layer with thickness of ~ 300–800 μm. A hierarchical porous scaffold was obtained with macro, micro and nanopores in the range of 400–900 μm, 1–120 μm and 40–290 nm, after salt leaching process. These scales could be easily adjusted based on the starting foam physical characteristics, salt particle size, viscosity of the paste and salt/PCL weight ratio. |
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