Short Chain Saturated Fatty Acids Decrease Circulating Cholesterol and Increase Tissue PUFA Content in the Rat |
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Authors: | Philippe Legrand Erwan Beauchamp Daniel Catheline Frédérique Pédrono Vincent Rioux |
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Affiliation: | Laboratoire de Biochimie-Nutrition Humaine, Agrocampus Ouest, INRA USC 2012, 65 rue de Saint-Brieuc, CS 84215, 35042, Rennes Cedex, France. |
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Abstract: | This study investigates the effect of various dietary saturated fatty acid (SFA) profiles on plasma lipid parameters and tissue
fatty acid composition in rats. The experiment was designed to monitor polyunsaturated fatty acids (PUFA) levels, while examining
different amounts and types of SFA. Four isocaloric diets were prepared, containing 10–11 mol% of fatty acids (FA) as linoleic
acid (LNA) and 2.5 mol% as α-linolenic acid (ALA), leading to an identical and well-balanced LNA/ALA ratio. The initial rapeseed
oil/corn oil mixture providing ALA and LNA was enriched with olive oil to prepare the olive oil diet. The butterfat diet was
supplemented with butterfat, containing short-chain SFA (C4:0–C10:0, 17 mol% of FA), lauric acid (C12:0, 3.2 mol%), myristic
acid (C14:0, 10.5 mol%) and palmitic acid (C16:0, 14.5 mol%). The saturates diet was supplemented with trilaurin, trimyristin
and tripalmitin to obtain the same level of lauric, myristic and palmitic acids as the butterfat diet, without the short-chain
SFA. The trimyristin diet was enriched with trimyristin only. The results showed that the butterfat diet contributed to specific
effects, compared to the olive oil diet and the saturates and trimyristin diets: a decrease in plasma total, LDL- and HDL-cholesterol,
higher tissue storage of ALA and LNA, and a higher level of (n-3) highly unsaturated fatty acids in some tissues. This study
supports the hypothesis that in diets with identical well-balanced LNA/ALA ratios, short chain SFA may decrease circulating
cholesterol and increase tissue polyunsaturated fatty acid content in the rat. |
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