| N-邻苯二甲酰-L-谷氨酸的合成工艺的研究 |
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| 引用本文： | 郝永兵,田拴宝,胡先明.N-邻苯二甲酰-L-谷氨酸的合成工艺的研究[J].广东化工,2011,38(1):11+9-11,9. |
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| 作者姓名： | 郝永兵 田拴宝 胡先明 |
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| 作者单位： | 郝永兵,Hao Yongbing(武汉大学,药学院,湖北,武汉,430072;新乡医学院,化学教研室,湖北,新乡,453003);田拴宝,Tian Shuanbao(新乡医学院,化学教研室,湖北,新乡,453003);胡先明,Hu Xianming(武汉大学,药学院,湖北,武汉,430072) |
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| 摘 要： | N-邻苯二甲酰-L-谷氨酸的合成工艺研究。以吡啶为溶剂，邻苯二甲酸酐和L-谷氨酸为原料酰化合成N-邻苯二甲酰-L-谷氨酸，讨论了影响酰化反应的各个因素。总收率可达91％。最优化工艺条件为溶剂用量吡啶（mL）：谷氨酸（g）=4：1；反应物配比n（邻苯二甲酸酐）：n（谷氨酸）=1．0：1．1；回流反应时间5．0h；脱水剂无水硫酸钠。
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| 关 键 词： | N-邻苯二甲酰-L-谷氨酸 邻苯二甲酸酐 L-谷氨酸 |
Study on Synthesis of N-phthaloyl-L-glutamic Acid |
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| Hao Yongbing,Tian Shuanbao,Hu Xianming.Study on Synthesis of N-phthaloyl-L-glutamic Acid[J].Guangdong Chemical Industry,2011,38(1):11+9-11,9. |
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| Authors: | Hao Yongbing Tian Shuanbao Hu Xianming |
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| Affiliation: | 1(1.College of Pharmacy,Wuhan University,Wuhan 430072;2.Department of Chemistry, Xinxiang Medical University,Xinxiang 453003,China) |
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| Abstract: | Study on synthesis of N-phthaloyl-L-glutamic Methods.N-phthaloyl-L-glutamic acid was synthesized with phthalic anhydrideand L-glutamic acid as raw materials and with pyridine as solvent.To obtain 91 % yield of N-phthaloyl-L-glutamic acid.The best is the molar ratio of phthalic anhydride to L-glutamic acid was 1∶1.1;the ratio of volume of pyridine to mass of L-glutamic acid was 4∶1;the reaction time was 5.0 h. |
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| Keywords: | N-phthaloyl-L-glutamic phthalic anhydride L-glutamic acid |
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