Presynaptic potassium channels |
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Authors: | J Roeper O Pongs |
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Affiliation: | Zentrum für Molekulare Neurobiologie, Institut für neurale Signalverarbeitung, Martinistrasse 52, Haus 42, D-20246 Hamburg, Germany. |
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Abstract: | The past year has witnessed some significant improvements in our understanding of the molecular diversity, subunit composition, and functional properties of K+ channels in heterologous expression systems. Immunocytochemical studies have yielded important information on the localization of K+ channel proteins to synaptic terminals in mammalian brain. Although a coherent picture of native presynaptic K+ channels' function in the mammalian central nervous system is not yet available, it may emerge from improvements in patch-clamp techniques and new applications of targeted knock-out technologies. |
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