Controlled drug delivery system based on magnetic hollow spheres/polyelectrolyte multilayer core-shell structure |
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Authors: | Zhang YanQi Lil LinLin Tang Fangqiong Ren Jun |
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Affiliation: | Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China. |
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Abstract: | A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core-shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core-shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics. |
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