MRI demonstration of impairment of the blood-CSF barrier by glucose administration to the thiamin-deficient rat brain |
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Authors: | FO Zelaya SE Rose PF Nixon BT Wholohan AJ Bower C Zimitat J Schoutrop DM Doddrell |
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Affiliation: | Centre for Magnetic Resonance, University of Queensland, St. Lucia, Brisbane, Australia. |
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Abstract: | Contrast-enhanced T1-weighted spin-echo magnetic resonance imaging (MRI) has demonstrated that Gd-diethylenetriaminepentaacetate (Gd-DTPA), which normally does not cross the blood-brain or blood-CSF barriers, does so approximately 40 min after administration of glucose to a vitamin B1 deficient rat. The period of the onset of this blood-CSF or blood-brain barrier dysfunction coincides with our previous observations of accumulation of glutamate or glutamate derivatives following an equivalent glucose load under identical conditions of thiamin deficiency, consistent with a relationship between these two observations. The dysfunction was reversed when a thiamin deficient animal was made thiamin replete. |
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