| 沙美特罗的合成 |
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| 引用本文： | 应敏,张华星.沙美特罗的合成[J].广东化工,2009,36(12):58-58,77. |
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| 作者姓名： | 应敏 张华星 |
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| 作者单位： | 1. 浙江万里学院,浙江,宁波,315100
2. 浙江大学,宁波理工学院,浙江,宁波,315100 |
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| 摘 要： | 以对羟基苯基丙烯酸为原料，通过羟甲基化得到3-羟甲基-4-羟基苯基丙烯酸，然后对3-羟甲基-4羟基-苯基丙烯酸的双键加成上羟基，再把羧酸还原成醛基，然后与4-苯氧丁基己胺缩合得到亚胺，加氢还原得到目标产物。
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| 关 键 词： | 沙美特罗 对羟基丙烯酸 合成 |
The Synthesis of Salmeterol |
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| Ying Min,Zhang Huaxing.The Synthesis of Salmeterol[J].Guangdong Chemical Industry,2009,36(12):58-58,77. |
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| Authors: | Ying Min Zhang Huaxing |
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| Affiliation: | Ying Min1,Zhang Huaxing2(1.Zhejian Wanli University,Ningbo 315100,2.Ningbo Institute of Technology,Zhejiang University,China) |
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| Abstract: | The Salmeterol was synthesized through 3-(4-hydroxyphenyl)acrylic acid as started materials.3-(4-hydroxy-3-(hydroxymethyl)phenyl)acrylic acid was prepared from 3-(4-hydroxyphenyl)acrylic acid through methyloated reaction.Then 3-(4-hydroxy-3-(hydroxymethyl)phenyl)acrylic acid was got from H2O addition reaction wtih double bond to get derivative 3-hydroxy-3-(4-hydroxy-3-(hydroxymethyl)phenyl)propanal.At last,the 3-hydroxy-3-(4-hydroxy-3-(hydroxymethyl)phenyl)propanal react with amino and addition with H2 to g... |
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| Keywords: | Salmeterol 3-(4-hydroxyphenyl)acrylic acid synthesis |
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