Feasibility, tailoring and properties of polyurethane/bioactive glass composite scaffolds for tissue engineering |
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Authors: | Francesco Baino Enrica Verné Chiara Vitale-Brovarone |
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Affiliation: | (1) Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy |
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Abstract: | This research work aims to propose highly porous polymer/bioactive glass composites as potential scaffolds for hard-tissue
and soft-tissue engineering. The scaffolds were prepared by impregnating an open-cells polyurethane sponge with melt-derived
particles of a bioactive glass belonging to the SiO2–P2O5–CaO–MgO–Na2O–K2O system (CEL2). Both the starting materials and the composite scaffolds were investigated from a morphological and structural
viewpoint by X-ray diffraction analysis and scanning electron microscopy. Tensile mechanical tests, carried out according
to international ISO and ASTM standards, were performed by using properly tailored specimens. In vitro tests by soaking the
scaffolds in simulated body fluid (SBF) were also carried out to assess the bioactivity of the porous composites. It was found
that the composite scaffolds were highly bioactive as after 7 days of soaking in SBF a HA layer grew on their surface. The
obtained polyurethane/CEL2 composite scaffolds are promising candidates for tissue engineering applications. |
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