微生物法生产1,3-丙二醇过程的代谢工程研究进展

代谢工程在微生物发酵法生产化工产品的过程中扮演着越来越重要的角色. 本研究以生物法生产1,3-丙二醇所涉及的关键酶、代谢途径及其改造为考察对象，系统综述了微生物法生产1,3-丙二醇所涉及的代谢工程技术、最新应用情况及其进展，并展望了未来的发展趋势.

Recent Developments in Microbial Metabolic Engineering for the Production of 1,3-Propanediol

Integration of metabolic engineering and fermentation production technologies is necessary for the successful commercial production of chemicals, For the case of biological production of 1,3-propanediol with glycerol, the natural strains are utilized to produce 1,3-propanediol, but the by-products inhibit the product yield for consuming reducing equivalents, however by means of metabolic engineering, this problem can be solved. Besides, by means of utilizing genes from natural strains that produce 1,3-propanediol from glycerol, a recombinant strain that utilizes the cheaper feedstock glucose can be realized, it will increase the competitiveness of the biological production of 1,3-propanediol, In this article, the metabolic engineering of the glycerol pathway and glucose pathway are reviewed respectively, as well as the recent developments and new trends,