Effect of tibric acid on hepatic cholesterol synthesis in rats |
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| Authors: | M. N. Cayen J. Dubuc D. Dvornik |
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| Affiliation: | (1) Department of Biochemistry, Ayerst Research Laboratories, H4R 1J6 Montreal, Quebec, Canada |
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| Abstract: | Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum cholesterol and triglyceride levels were reduced, but total liver content of cholesterol, phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [14C] acetate and [3H] mevalonate into cholesterol by liver homogenates. |
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