| 1-(2-丙基)戊酰基-5-取代苯基-3-吡唑烷酮衍生物的合成及抗癫痫作用研究 |
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| 引用本文： | 李福男,全哲山,任艳梅.1-(2-丙基)戊酰基-5-取代苯基-3-吡唑烷酮衍生物的合成及抗癫痫作用研究[J].化学试剂,2004,26(2):95-96. |
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| 作者姓名： | 李福男 全哲山 任艳梅 |
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| 作者单位： | 延边大学,药学院,吉林,延吉,133000;吉林平安行药业,吉林,长春,130000 |
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| 摘 要： | 以取代苯甲醛为起始原料，经缩合、酯化、环合及酰化，合成了5个新的化合物5-取代苯基-3-吡唑烷酮衍生物，用IR,^1HNMR及MS对其结构进行了表征。经初步生物活性测定表明，化合物4e显示出较强的抗癫痫活性。
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| 关 键 词： | 3-吡唑烷酮 抗癫痫作用 合成 |
| 文章编号： | 0258-3283(2004)02-0095-02 |
Synthesis and research of antiepileptic activities of 1-(2-propyi ) pentanoyl-5-substitued phenyl-3-pyrazolidinosesderivatives |
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| LI Fu-nan,QUAN Zhe-shan,REN Yan-mei.Synthesis and research of antiepileptic activities of 1-(2-propyi ) pentanoyl-5-substitued phenyl-3-pyrazolidinosesderivatives[J].Chemical Reagents,2004,26(2):95-96. |
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| Authors: | LI Fu-nan QUAN Zhe-shan REN Yan-mei |
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| Affiliation: | LI Fu nan *1,QUAN Zhe shan 1,REN Yan mei 2 |
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| Abstract: | These objective compounds were synthesized through condensation,esterification,ring closure and acylation steps using benzaldehyde as a starting material.Five new derivatives of 5 substituted phenyl 3 pyrazolidinoses were synthesized,their structures were confirmed by IR, 1HNMR and MS.Preliminary test of biological activities showed that compound 4e had appreciable antiepileptic activity. |
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| Keywords: | pyrazolidinones antiepileptic activity synthesis |
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