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| 头孢替安中间体N,N-二甲基氨基乙基-5-巯基-四氮唑的合成研究 | |
| 引用本文： | 杜会茹,马东来,孙威,郝六平.头孢替安中间体N,N-二甲基氨基乙基-5-巯基-四氮唑的合成研究[J].河北化工,2011,34(9):10-11,32. |
| 作者姓名： | 杜会茹 马东来 孙威 郝六平 |
| 作者单位： | 1. 河北化工医药职业技术学院制药工程系,河北石家庄,050026 2. 河北大学化学与环境科学学院,河北保定,071002 3. 中国地质科学院水文地质-环境地质研究所,河北石家庄,050803 |
| 摘 要： | N,N-二甲基氨基乙基-5-巯基-四氮唑（DMMT）为合成头孢替安的关键中间体。N,N-二甲基乙二胺与CS2加成后,不经巯基保护,直接与NaN3闭环合成得到产品,总收率达到75.4%。对实验条件进行了优化。 |
| 关 键 词： | 头孢替安中间体 N N-二甲基氨基乙基-5-巯基-四氮唑（DMMT） N N-二甲基乙二胺 CS2 合成 |
Synthesis of 1-(2-(Dimethylamino)ethyl)-1,2-dihydrotetrazole-5-thione |
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| DU Hui-ru ,MA Dong-lai ,SUN Wei ,HAO Liu-ping.Synthesis of 1-(2-(Dimethylamino)ethyl)-1,2-dihydrotetrazole-5-thione[J].Hebei Chemical Engineering and Industry,2011,34(9):10-11,32. | |
| Authors: | DU Hui-ru MA Dong-lai SUN Wei HAO Liu-ping |
| Affiliation: | DU Hui-ru 1,MA Dong-lai 2,SUN Wei 3,HAO Liu-ping 1(1.Hebei Chemical & Pharmaceutical College,Pharmaceutical Engineering,Shijiazhuang 050026,China,2.College of Chemistry & Environ-mental Science,Hebei University,Baoding 071002,3.Hydro-geological & Environment-geological Institute,Chinese Academy of Geological Sciences,Shijiazhuang 050803,China) |
| Abstract: | 1-(2-(Dimethylamino)ethyl)-1,2-dihydrotetrazole-5-thione(DMMT) is a key intermediate compound for Cefoti-am.It was obtained by having a addition reaction with N,N-dimethylethane-1,2-diamine and CS 2,then reacting with NaN 3 directly in the condition of no the sulfhydryl group protection.The total yields reached 75.4%.The optimum reaction con-ditions was found in the experiment. |
| Keywords: | key intermediate compound of cefotiam 1-[2-(dimethylamino)-ethyl]-1 2-dihydrotetrazole-5-thione(DMMT) N N-dimethylethane-1 2-diamine CS 2 synthesis |
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