| 一种盐酸吡格列酮简便合成工艺研究 |
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| 引用本文： | 牛志刚,李志刚,蔡红光. 一种盐酸吡格列酮简便合成工艺研究[J]. 河北化工, 2011, 0(11): 22-24 |
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| 作者姓名： | 牛志刚 李志刚 蔡红光 |
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| 作者单位： | 沧州那瑞化学科技有限公司; |
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| 摘 要： | 报道了一种新的合成治疗糖尿病药物盐酸吡格列酮工艺。以活性KOH为缩合催化剂,5-乙基-2-羟乙基吡啶与对氟苯甲醛缩合得到4-{2-（5-乙基-2-吡啶基）乙氧基}苯甲醛,再与2,4-噻唑烷二酮进行缩合,利用复合型Ni-Cu-Fe催化剂催化加氢还原,再经盐酸酸化成盐得盐酸吡格列酮。
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| 关 键 词： | 盐酸吡格列酮 KOH 复合型Ni-Cu-Fe催化剂 循环利用 |
Study on Synthesis Process Conditions of Pioglitazone hydrochloride |
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| NIU Zhi-gang,LI Zhi-gang,CAI Hong-guang. Study on Synthesis Process Conditions of Pioglitazone hydrochloride[J]. Hebei Chemical Engineering and Industry, 2011, 0(11): 22-24 |
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| Authors: | NIU Zhi-gang LI Zhi-gang CAI Hong-guang |
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| Affiliation: | NIU Zhi-gang,LI Zhi-gang,CAI Hong-guang(Senary Chemical Science-tech Co.,Ltd,Cangzhou 061000,China) |
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| Abstract: | To report a new synthesis process of pioglitazone hydrochloride for treating diabetes.With activated potassium hydroxide as catalyst,2-(5-ethyl-2-pyridyl)ethanol was condensed with 4-fluorobenzaldehyde to give 4-[2-(5-ethyl-2-pyridyl)oxethyl]benzaldehyde,then was condensed with 2,4-thiazolidinedione.The product pioglitazone hydrochloride was obtained by hydrogen reduction with composite catalyst of Ni-Cu-Fe,and then acidifying with hydrochloride acid. |
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| Keywords: | pioglitazone hydrochloride potassium hydroxide catalyst composite catalyst of Ni-Cu-Fe recycling use |
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