Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning |
| |
| Authors: | A Shigenari A Ando T Baba T Yamamoto Y Katsuoka H Inoko |
| |
| Affiliation: | Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan. |
| |
| Abstract: | Two members of a placental alkaline phosphatase (PLAP) family, PLAP and PLAP-like or germ cell alkaline phosphatase, are aberrantly expressed in tumors of ecotropic origin. To characterize alkaline phosphatase induced in seminoma, alkaline phosphatase cDNA clones were isolated from a cDNA library constructed from seminoma cells and characterized by nucleotide sequence determination. Thus, isolated cDNA clones were classified into two types, germ cell alkaline phosphatase (PLAP-like) and liver/bone/kidney-type alkaline phosphatase (L/B/K AP). These results suggest that other than the PLAP family members, the expression of L/B/K AP is enhanced in seminoma and can serve as a tumor marker in seminoma. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
