Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains |
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Authors: | BA Irving FW Alt N Killeen |
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Affiliation: | Department of Microbiology and Immunology, University of California, San Francisco, CA 94143-0414, USA. |
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Abstract: | Immature thymocytes express a pre-T cell receptor (pre-TCR) composed of the TCRbeta chain paired with pre-Talpha. Signals from this receptor are essential for passage of thymocytes through a key developmental checkpoint in the thymus. These signals were efficiently delivered in vivo by a truncated form of the murine pre-TCR that lacked all of its extracellular immunoglobulin domains. De novo expression of the truncated pre-TCR or an intact alphabetaTCR was sufficient to activate characteristic TCR signaling pathways in a T cell line. These findings support the view that recognition of an extracellular ligand is not required for pre-TCR function. |
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