Glycosylation assists binding of HIV protein gp120 to human CD4 receptor |
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| Authors: | Wilhelm Dennis Behnken Henning N Meyer Bernd |
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| Affiliation: | Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany. |
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| Abstract: | The role of glycosylation of proteins on its binding affinity is not well understood. Even a monosaccharide (magenta) placed at a glycosylation site can significantly enhance binding of peptides to their receptor. If glycosylated, an HIV protein binds stronger and faster to its primary receptors on human cells. |
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| Keywords: | glycobiology glycopeptides protein–ligand interactions STD NMR surface plasmon resonance |
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