Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells |
| |
| Authors: | H Kaneko LP Neoh N Takeda H Akimoto T Hishikawa H Hashimoto S Hirose S Karaki M Takiguchi H Nakauchi Y Kaneko N Yamamoto I Sekigawa |
| |
| Affiliation: | Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan. |
| |
| Abstract: | We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
