Intercalation of Ga3 +-salicylidene-amino acid Schiff base complexes into layered double hydroxides: Synthesis,characterization, acid resistant property,in vitro release kinetics and antimicrobial activity |
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| Affiliation: | 1. College of Chemistry, Beijing Normal University, Beijing 100875, China;2. College of Life Science, Beijing Normal University, 100875, China;1. Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, Harbin Normal University, Harbin 150025, China;2. Key Laboratory of Photochemical Biomaterialsand Energy Storage Material, Heilongjiang Province, Harbin Normal University Harbin, 150025, China;1. MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081, China;2. Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China;3. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China;1. School of Metallurgy and Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China;2. Xi’an GaoxinNo.1 High School, Xi’an 710056, China |
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| Abstract: | This study is aimed to evaluate the potential application of a drug delivery system of Ga3 + complexes in layered double hydroxide, i.e. Ga(L)2]−-LDH (L represents Schiff base ligands made up of salicylidene with glycine, alanine, tyrosine, phenylalanine, aspartic acid and glutamic acid for complexes 1–6, respectively). The successful intercalation of Ga3 + complexes into Mg/Al-NO3-LDH by delaminating/restacking method was proved by elemental analysis, XRD, FTIR spectra, UV–vis DR spectra, TG analysis and SEM measurements. A monolayer intercalation of 5 and 6, bilayer of 1 and 3 and trilayer of 2 and 4 in interlayer region of hybrids which have extended gallery height of 11.86–21.22 Å were deduced. Better acid resistance than the pristine complexes in wide pH range from 7 to 1 was revealed by UV–vis spectra. The cumulative release profile of Ga3 + complexes from the hybrids in phosphate buffer (pH 7.4) following first-order kinetics via ion-exchange between guest anions and phosphate anions was established by UV–vis spectra. Antibacterial activity of hybrids with MIC values of 65–137 μmol/L against Pseudomonas aeruginosa was demonstrated by the broth twofold dilution method. These results suggest that LDH is a promising host material for carry and controlled delivery of biologically active Ga3 + complexes. |
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