Chiral separation by combining pertraction and preferential crystallization |
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| Affiliation: | 1. Karlsruhe Institute of Technology (KIT), Institute for Technical Thermodynamics and Refrigeration, Engler-Bunte-Ring 21, D-76131 Karlsruhe, Germany;2. Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D-39106 Magdeburg, Germany;3. RWTH Aachen University, Institute for Technical Thermodynamics, Schinkelstraße 8, D-52062 Aachen, Germany;1. National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, PR China;2. Guangdong Provincial Key Lab of Green Chemical Product Technology, PR China;1. College of Materials Science and Engineering, Hunan University, Changsha 410082, China;2. School of Engineering, University of Warwick, Coventry CV4 7AL, UK;3. School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, UK;1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan;2. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan;1. Departamento de Química Física y Analítica, Universidad de Jaén, Campus Las Lagunillas, E-23071 Jaén, Spain;2. Departamento de Química Orgánica y Bio-Orgánica, Facultad de Ciencias, Universidad Nacional de Educación a Distancia (UNED), Senda del Rey 9, E-28040 Madrid, Spain;3. Instituto de Química Médica (CSIC), Juan de la Cierva, 3, E-28006 Madrid, Spain |
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| Abstract: | This work describes the application of a hybrid two-step enantioselective separation process. As a first step, pertraction using supported liquid membranes provides an initial enrichment, while the following preferential crystallization delivers the enantiopure crystals as final product. Mandelic acid in water was studied as a model system. Using a suitable chiral selector, pertraction provides enrichments exceeding 10% and reaching up to 20% in the permeate phase, which was sufficient to allow for subsequent selective preferential crystallization. Based on the individual performances of pertraction and crystallization, overall yields and productivities are estimated. The calculated productivities are compared with values achievable in alternatively applicable chromatographic separation processes using chiral stationary phases. The realized hybrid pertraction-crystallization process is in its present state for the example considered still inferior to preparative chromatography. Strategies for further improvement are suggested. |
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