Detection of polyomavirus DNA in human brain tumors |
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| Authors: | Vasilyeva Iryna G Shamaev Mikhail I Glavatskiy Alexandr Ya Chopick Natalya G Olexenko Natalya P Tsyubko Olga I Galanta Elena S Malisheva Tatyana A |
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| Affiliation: | A.P. Romodanov Institute of Neurosurgery of Academy of Medical Sciences of Ukraine, Kyiv, Ukraine. ira@neuro.kiev.ua |
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| Abstract: | AIM: To investigate surgically resected human brain tumors for the presence of polyomavirus DNA. MATERIALS AND METHODS: 65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis. RESULTS: DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed. CONCLUSION: Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection. |
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