| 头孢呋新酯的合成改进 |
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| 引用本文： | 蒋海珍,浦家齐.头孢呋新酯的合成改进[J].化学世界,2001,42(10):529-530. |
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| 作者姓名： | 蒋海珍 浦家齐 |
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| 作者单位： | 上海大学化学系, |
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| 摘 要： | 将头孢呋新钠溶于偶极非质子性溶剂 N,N-二甲基乙酰胺 ( DMAC)溶液中 ,加入三乙胺( Et3N) ,在室温下 ,滴加 1 -乙酰氧 - 1 -溴乙烷 ,高产率合成头孢呋新酯。产品结构用 IR,1H NMR与HPLC验证
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| 关 键 词： | 头孢呋新酯 偶极非质子性溶剂 酯化反应 |
| 文章编号： | 0367-6358(2001)10-0529-02 |
Improved Synthesis of Cefuroxime Axetil |
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| JIANG Hai zhen,PU Jia qi.Improved Synthesis of Cefuroxime Axetil[J].Chemical World,2001,42(10):529-530. |
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| Authors: | JIANG Hai zhen PU Jia qi |
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| Abstract: | Acetoxyethyl bromide was added dropwise into a suspension of sodium Cefuroxime in dimethyl acetamide in the presense of Et 3N at room temperature. Cefuroxime Axetil was obtained in high yield. The structure and purity of the product were confirmed by IR, 1H NMR and HPLC. |
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| Keywords: | Cefuroxime Axetil dipolar aprotic solvent esterification reaction |
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