Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer |
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Authors: | Hongwei Chen Julie Yeh Liya Wang Hafsa Khurshid Nan Peng Andrew Y Wang Hui Mao |
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Affiliation: | (1) Functional Materials Division, Royal Institute of Technology, 16440 Kista, Sweden;(2) Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 7000 Mons, Belgium; |
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Abstract: | We report the application of a versatile diblock copolymer, poly(ethylene oxide)-b-poly(γ-methacryloxypropyl trimethoxysilane)
(PEO-b-PγMPS), to prepare nanocrystals such as iron oxide nanoparticles or quantum dots, with either a single core or multi-core
cluster, for biomedical applications. This amphiphilic copolymer comprises both a hydrophilic PEO segment and a hydrophobic
segment with a “surface anchoring moiety” (the silane group) which can interact effectively with the hydrophobic nanocrystals
through ligand exchange. One of the unique features of this work is that we can control the formation of either single core
nanoparticles or multi-core nanoclusters by simply varying the conditions of ligand exchange and aging of the mixture of block
copolymer and nanoparticles without needing to change the copolymer. The morphologies of the resulting single core nanoparticles
or multi-core nanoclusters were confirmed by dynamic light scattering and transmission electron microscopy. The clustered
nanoparticles exhibit enhanced physicochemical properties that are beyond those expected from a simple accumulation of individual
nanoparticles. Additionally, the hybrid nanoparticles containing both magnetic iron oxide nanoparticles and optical quantum
dots obtained using our strategy provide have combined magnetic and optical functionalities that allow for potential new and
expanded biomedical applications, as demonstrated by their use for magnetic resonance imaging and biomarker-targeted cell
imaging. |
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