| 仿生壳聚糖基纳米纤维的自组装构建 |
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| 引用本文： | 曾戎,刘宏伟,屠美,赵剑豪,查振刚,周长忍. 仿生壳聚糖基纳米纤维的自组装构建[J]. 高分子材料科学与工程, 2009, 0(12) |
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| 作者姓名： | 曾戎 刘宏伟 屠美 赵剑豪 查振刚 周长忍 |
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| 作者单位： | 暨南大学材料科学与工程系;人工器官与材料教育部工程研究中心;暨南大学附属第一医院; |
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| 基金项目： | 国家自然科学基金资助项目(20504018); 国家高新技术发展计划(2007AA09Z440) |
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| 摘 要： | 通过天然阳离子型高分子壳聚糖与三聚磷酸钠的静电自组装,制备模仿细胞外基质纳米结构的仿生壳聚糖基纳米纤维。研究了介质、壳聚糖浓度、反应物比例、添加胶原等因素对自组装复合产物的影响;并采用透射电镜、X射线衍射和红外光谱等技术表征了纳米纤维的结构。结果表明,介质对壳聚糖基纳米复合物的结构和形态的影响很大;以己二酸溶液为介质,在温和条件下,可获得结构可控的壳聚糖基纳米纤维,有望用于构建模仿天然细胞外基质的组织工程支架。
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| 关 键 词： | 壳聚糖 静电自组装 仿生 纳米纤维 |
Fabrication of Biomimetic Chitosan-Based Nanofibers by Self-Assembly |
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| ZENG Rong,LIU Hong-wei,TU Mei,ZHAO Jian-hao, ZHA Zhen-gang,ZHOU Chang-ren. Fabrication of Biomimetic Chitosan-Based Nanofibers by Self-Assembly[J]. Polymer Materials Science & Engineering, 2009, 0(12) |
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| Authors: | ZENG Rong LIU Hong-wei TU Mei ZHAO Jian-hao ZHA Zhen-gang ZHOU Chang-ren |
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| Affiliation: | ZENG Rong1,2,LIU Hong-wei1,TU Mei1,ZHAO Jian-hao1,2 ZHA Zhen-gang2,3,ZHOU Chang-ren1,2 (1.Department of Materials Science and Engineering,College of Science and Engineering,Jinan University,2.Engineering Research Center of Artificial Organs and Materials,Ministry of Education,Guangzhou 510632,China,3.Guangzhou Overseas Chinese Hospital,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China) |
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| Abstract: | Biomimetic polymeric nanofibers have received increasing interests for tissue engineering due to their structural similarity to extracellular matrix(ECM) recently.In this work,biomimetic chitosan-based nanofibers were successfully prepared by electrostatic self-assembly of chitosan and tripolyphosphate(TPP) with the help of adipic acid under mild conditions,and characterized using transmission electron microscopy(TEM),X-ray diffraction(XRD) and Fourier-transform infrared(FT-IR) spectroscopy.Factors affectin... |
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| Keywords: | chitosan electrostatic self-assembly biomimetic nanofibers |
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