Gold‐Coated Fe3O4 Nanoroses with Five Unique Functions for Cancer Cell Targeting,Imaging, and Therapy |
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| Authors: | Chunmei Li Tao Chen Ismail Ocsoy Guizhi Zhu Emir Yasun Mingxu You Cuichen Wu Jing Zheng Erqun Song Cheng Zhi Huang Weihong Tan |
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| Affiliation: | 1. Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, USA;2. Ministry of Education Key Laboratory on Luminescence and Real‐Time Analysis, College of Chemistry and Chemical Engineering College of Pharmaceutical Science, Southwest University, Chongqing, China;3. Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China |
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| Abstract: | The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis and therapy will provide the multimodality needed for accurate diagnosis and targeted therapy. Here, gold‐coated iron oxide (Fe3O4@Au) nanoroses with five distinct functions are demonstrated, integrating aptamer‐based targeting, magnetic resonance imaging (MRI), optical imaging, photothermal therapy. and chemotherapy into one single probe. The inner Fe3O4 core functions as an MRI agent, while the photothermal effect is achieved through near‐infrared absorption by the gold shell, causing a rapid rise in temperature and also resulting in a facilitated release of the anticancer drug doxorubicin carried by the nanoroses. Where the doxorubicin is released, it is monitored by its fluorescence. Aptamers immobilized on the surfaces of the nanoroses enable efficient and selective drug delivery, imaging, and photothermal effect with high specificity. The five‐function‐embedded nanoroses show great advantages in multimodality. |
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| Keywords: | nanoroses chemotherapy photothermal therapy cancer cells imaging |
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