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Nanometric Micelles with Photo‐Triggered Cytotoxicity |
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| Authors: | Parambath Anilkumar Edmond Gravel Ioanna Theodorou Karine Gombert Benoit Thézé Frédéric Ducongé Eric Doris |
| Affiliation: | 1. CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif‐sur‐Yvette, France;2. CEA, I2BM, Molecular Imaging Research Center (MIRCen), Fontenay‐aux‐Roses, France;3. CNRS, Unité de Recherche Associée CEA‐CNRS2210, Fontenay‐aux‐Roses, France;4. CEA, I2BM, Service Hospitalier Frédéric Joliot (SHFJ), Orsay, France;5. INSERM U1023, Laboratoire d’Imagerie Moléculaire Expérimentale, Orsay, France;6. Université Paris Sud, Orsay, France |
| Abstract: | The development of a photo‐responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo‐labile nitrobenzyl group. The resulting amphiphilic units are self‐assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo‐irradiation, micelles undergo cleavage and yield a cytotoxic nitrosobenzaldehyde derivative, which significantly inhibits the proliferation of MDA‐MB‐231 cells under standard in vitro conditions. |
| Keywords: | nanomedicine micelles nitrobenzyl photo‐triggered cytotoxicity |