| 用Skraup反应合成7-氯喹哪啶 |
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| 引用本文： | 李树安,张珍明,张喆,刘嵘森,葛洪玉. 用Skraup反应合成7-氯喹哪啶[J]. 淮海工学院学报, 2007, 16(3): 49-51 |
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| 作者姓名： | 李树安 张珍明 张喆 刘嵘森 葛洪玉 |
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| 作者单位： | 淮海工学院化学工程系,江苏连云港222005 |
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| 基金项目： | 江苏省高校高新技术产业发展项目 , 江苏省教育厅青蓝工程项目 |
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| 摘 要： | 研究了以邻硝基甲苯为氧化剂,间氯苯胺和巴豆醛通过经典的Skraup反应制备7-氯喹哪啶的改进方法.7-氯喹哪啶的收率为46.7%,质量分数99.2%;副产物为二氯喹哪啶,收率13.4%.还考察了氧化剂、氧化剂的用量以及盐酸的浓度对7-氯喹哪啶收率的影响.在1 000 L反应釜上做了放大实验,共生产7 t 7-氯喹哪啶,质量和收率达到了小试的结果.
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| 关 键 词： | 7-氯喹哪啶 间氯苯胺 巴豆醛 邻硝基甲苯 Skraup合成 中试放大 |
| 文章编号： | 1672-6685（2007）03-0049-03 |
| 修稿时间： | 2007-06-01 |
Synthesis of 7-Chloroquinaldine by Skraup Reaction |
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| LI Shu-an,ZHANG Zhen-ming,ZHANG Zhe,LIU Rong-sen,GE Hong-yu. Synthesis of 7-Chloroquinaldine by Skraup Reaction[J]. Journal of Huaihai Institute of Technology:Natural Sciences Edition, 2007, 16(3): 49-51 |
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| Authors: | LI Shu-an ZHANG Zhen-ming ZHANG Zhe LIU Rong-sen GE Hong-yu |
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| Affiliation: | Dept. of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China |
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| Abstract: | Using o-nitrotoluene as an oxidant, the improved preparation of 7-chloroquinldine was studied by classical Skraup reaction of m-chloroaniline and crotonaldehyde. 7-chloroquinaldine was obtained with the yield rate of 46.7% and the purity of 99.2%. The side product was obtained and elucidated as dichloroquinaldine with the yield of 13.4%. The effect of oxidant, amount of oxidant and concentration of hydrochloric acid on the yield of 7-chloroquinaldine was also investigated. Scale-up of this procedure in the reactor of 1 000 L was carried out to yield 7 tons of 7- chloroquinaldine. The yield and quality of the product were the same as that of laboratory-scale. |
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| Keywords: | 7-chloroquinaldine m-chloroaniline crotonaldehyde o-nitrotoluene Skraup synthesis scale-up |
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