Pharmacokinetic-pharmacodynamic relationships between pirarubicin exposure and hematotoxicity: clinical application using only one blood sample

This paper addresses the axial stiffness of human lumbar motion segments while subjected to moderate loads. Impacts in axial direction were applied to Functional Spinal Units while they were subjected to weights acting as static pre-load. Accelerations were recorded proximal and distal of the FSU. The transfer function and the resonant frequency were calculated from this data. The stiffness was calculated from the resonant frequency and the load. A simple non-linear model was fitted to the data and a linear relationship was found between stiffness squared and force. The non-linear component in the model strongly affected the stiffness within the chosen load range. The present model may allow in vivo dynamic force determination with improved accuracy, e.g. in experiments where accelerometers have been fixated to pins inserted into the spinous processes of lumbar vertebrae if the static force is known.