铁皮石斛有效成分分析方法研究进展

基于CiteSpace知识图谱与专利分析，探讨铁皮石斛的研究热点与发展趋势。通过系统检索中国知网（CNKI）数据库和Web of Science（WOS）核心合集数据库关于铁皮石斛的中、英文文献，运用CiteSpace 5.8.R3软件对关键词信息绘制知识图谱，进行铁皮石斛发展历程与研究热点的可视化分析，并结合专利计量学研究手段分析铁皮石斛相关专利的领域分布与发展趋势，以及铁皮石斛在食品应用开发方面的专利情况。结果表明，研究热点国内外各有侧重，国内专注于铁皮石斛多糖、保健功能、化学成分、产品开发及基因等研究，国外偏向于动物实验及安全性评价等临床实验研究，在活性成分鉴定、药理作用及作用机制等领域研究较多。专利计量分析发现铁皮石斛食品种类丰富且大多为明确保健功能的食品，共涉及9种保健功能，其中以增强免疫力为主，占比42.04%，铁皮石斛在食品领域可在不同保健功能开发，产品制备技术以及铁皮石斛花、叶上进一步进行研究。本研究为分析铁皮石斛的研究内容、判断研究热点及食品专利申请方向提供参考。

Research progress in analysis methods of effective components of Dendrobium candidum

To explore the research hotspots and development trend of Dendrobium candidum based on CiteSpace knowledge map and patent analysis. Based on the Chinese and English literatures collected from CNKI and Web of Science, the knowledge map about keywords was constructed by using the visual analysis software CiteSpace 5.8.R3 to explore and analyze the reserach situation, the development trend and research hotspots of Dendrobium candidum. Combined with patent bibliometrics, the distribution and development trend of related patent fields of Dendrobium candidum were analyzed, and the food patents of Dendrobium candidum were investigated. The results showed that domestic research focused on Dendrobium candidum polysaccharides, health function, chemical constituents, product development and gene, while foreign research tends to clinical experiments, such as animal experiments and safety evaluation. There were many researches in the fields of active ingredient identification, pharmacological action and mechanism. Dendrobium officinale had a rich variety of foods, most of which were foods with clear health functions. A total of 9 health functions were involved, which was 42.04% to enhance immunity. Dendrobium candidum could be further studied in the field of food for different health functions, product preparation techniques, and flowers and leaves. This study would provide a reference for analyzing the research content of Dendrobium candidum, identifying research hotspots, and determining the direction of food patent applications.