实验性高脂血症动物模型比较分析

目的：探究玉米阿魏酸对高脂血症大鼠脂代谢和肝损伤的影响，以期提升玉米皮的附加值，为玉米阿魏酸的保健功效提供理论依据和数据支持。方法：随机选取8只大鼠作为正常组，其余大鼠给予高脂饲料喂养建立高脂血症大鼠模型。将高脂血症大鼠随机分为阳性对照组、模型组和玉米阿魏酸高、中、低剂量组。灌胃42 d后，测定大鼠肝脏指数、血脂、抗氧化指标，观察肝脏切片。结果：与模型组相比，玉米阿魏酸使高脂血症大鼠体重增长率降低0.23%、肝脏指数降低0.14%、高脂血症大鼠总胆固醇（TC）降低25.45%、甘油三酯（TG）降低52%、低密度脂蛋白胆固醇（LDL-C）降低48.28%、谷丙转氨酶（ALT）降低29.81%、谷草转氨酶（AST）降低16.63%、丙二醛（MDA）含量降低51.95%，超氧化物歧化酶（SOD）增加123.54%、谷胱甘肽过氧化物酶（GPH-Px）增加153.89%、过氧化氢酶（CAT）增加209.9%、高密度脂蛋白胆固醇（HDL-C）增加56.76%；玉米阿魏酸减少了高脂血症大鼠肝脏组织中脂滴空泡，改善了高脂血症大鼠肝脏组织结构。结论：玉米阿魏酸可降低高脂血症大鼠体重、肝脏指数，改善血脂代谢，提高抗氧化性，减轻高血脂症对肝脏的损伤。

Hyperlipidemia

Objective: To investigate the effects of corn ferulic acid on lipid metabolism and liver injury in hyperlipidemic rats. Significance: To improve the added value of corn husk and provide theoretical basis and data support for the health effect of corn ferulic acid. Methods: Eight rats were randomly selected as the normal group, and the rest rats were fed with high-fat diet to establish the hyperlipidemia rat model. The hyperlipidemia rats were randomly divided into positive control group, model group and corn ferulic acid high, medium and low dose groups. After 42 days of gavage, the liver index, blood lipid, antioxidant index and liver sections were measured. Results: Compared with the model group, corn ferulic acid reduced 0.23% of the body weight growth rate and 0.14% of the liver index of the hyperlipidemic rats. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) in hyperlipidemic rats were decreased by 25.45%, 52%, 48.28%, 29.81%, 16.63%, and 51.95%, respectively. The contents of superoxide dismutase (SOD), glutathione peroxidase (GPH-Px), catalase (CAT) and high-density lipoprotein cholesterol (HDL-C) were increased by 123.54%, 153.89%, 209.9% and 56.76%. Corn ferulic acid can improve the liver tissue structure of hyperlipidemia rats. Conclusion: Corn ferulic acid can reduce the body weight and liver index of hyperlipidemia rats, improve blood lipid metabolism, improve antioxidant ability, and alleviate liver damage caused by hyperlipidemia.