123I-MIBG的制备及动物实验研究

采用亚铜离子催化法制备¹²³I-MIBG，对其制备条件进行了优化，并研究了所制备的¹²³I-MIBG在常温下存放的稳定性以及在正常小鼠体内的生物分布情况。采用优化后的标记条件，¹²³I-MIBG的标记率可达95%以上，制得的不同浓度和比活度的¹²³I-MIBG室温下至少可稳定存放48h以上，显示出其良好的体外稳定性。体内生物分布数据显示：¹²³I-MIBG在肾上腺有最高的摄取(6.18±1.01)%ID?g^-1，且在48h内一直保持着较强的吸收；在心、肝、脾、肺、胃肠中也均有一定的摄取，但在血中的摄取量较低。¹²³I-MIBG在组织内的吸收与代谢趋势与文献报道结果相一致。

Preparation of 123I-MIBG and Animal Experiment

Metaiodobenzyl guanidine (MIBG) was labeled with ¹²³I using the catalyst of cuprous. The stability in vitro at atmospheric temperature and the biodistribution in normal mouse of ¹²³I-MIBG were studied. The labeling yield is over 95% at optimizing labeling conditions. The prepared ¹²³I-MIBG shows high stability after incubating at room temperature for over 48 h with different radioactive concentrations and specific activities. The highest uptake of ¹²³I-MIBG with (6.18±1.01) %ID?g^-1 is found in adrenals 1 h after injection according to the result of in vivo biodistribution in mouse. There are uptake in heart, lung, kidney and intestine, but the uptake in blood is low. The biodistribution and metabolism of ¹²³I-MIBG are accordance with reported results.