| 普拉格雷的合成 |
| |
| 引用本文： | 彭锡江,刘烽,何锡敏,潘仙华.普拉格雷的合成[J].精细化工,2011,28(2):156-161. |
| |
| 作者姓名： | 彭锡江 刘烽 何锡敏 潘仙华 |
| |
| 作者单位： | 上海应用技术学院,香料香精技术与工程学院,上海,200235 |
| |
| 摘 要： | 以4,5,6,7-四氢噻吩并3,2-c]吡啶为起始原料,经苄基保护、溴化、醚化和脱保护4步反应得到2-甲氧基-4,5,6,7-四氢噻吩并3,2-c]吡啶(Ⅺ);以邻氟苄溴为原料,经过格氏缩合、溴代两步反应,得到α-环丙羰基-2-氟苄溴(ⅩⅢ);将该两个化合物再经缩合反应、水解反应和乙酰化反应,以34.6%总收率得到目标化合物;其中部分中间体和目标化合物的结构经1HNMR和MS等进行了表征。
|
| 关 键 词： | 抗血栓 α-环丙羰基-2-氟苄溴 4 5 6 7-四氢噻吩并[3 2-c]吡啶 普拉格雷 医药与日化原料 |
Synthesis of Prasugrel |
| |
| PENG Xi-jiang,LIU Feng,HE Xi-min,PAN Xian-hua.Synthesis of Prasugrel[J].Fine Chemicals,2011,28(2):156-161. |
| |
| Authors: | PENG Xi-jiang LIU Feng HE Xi-min PAN Xian-hua |
| |
| Affiliation: | PENG Xi-jiang,LIU Feng,HE Xi-min,PAN Xian-hua(School of Perfume and Aroma Technology,Shanghai Institute of Technology,Shanghai 200235,China) |
| |
| Abstract: | The condensation precursor(Ⅺ) was synthesized via four steps from 4,5,6,7-tetrahydrothienopyridine hydrochloride.Another precursor(Ⅹ Ⅲ) of the condensation reaction was synthesized via two steps from 1-(bromomethyl)-2-fluorobenzene.The target product was prepared via condensation,hydrolysis and acetylation reactions from the two precursors.The yield is 34.6% in the overall seven steps.Some intermediates and target product were identified by 1HNMR and MS. |
| |
| Keywords: | anti-thrombosis 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone 4 5 6 7-tetra-hydrothieno pyridine prasugrel drug and cosmetic materials |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
