| N-苯基吡咯烷的微波合成 |
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| 引用本文： | 梁伍,李鸿波,刘浪,陈凯,吴毅,王龙飞.N-苯基吡咯烷的微波合成[J].精细化工,2011,28(2):188-190. |
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| 作者姓名： | 梁伍 李鸿波 刘浪 陈凯 吴毅 王龙飞 |
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| 作者单位： | 西南科技大学,材料科学与工程学院,四川,绵阳,621010 |
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| 摘 要： | 以苯胺和1,4-丁二醇二甲磺酸酯为原料,在缚酸剂存在下微波反应生成N-苯基吡咯烷。采用单因素实验及正交实验法考察了溶剂、缚酸剂、温度、时间、原料配比、功率对反应收率的影响,获得最佳工艺条件为:以水作溶剂,碳酸钾作缚酸剂,反应温度100℃,辐照时间60 min,原料配比:n(苯胺)∶n(1,4-丁二醇二甲磺酸酯)∶n(碳酸钾)=1∶1.3∶1.3,微波功率200 W,在该条件下收率可达78.6%。该工艺条件具有反应迅速、条件温和、处理简单、产品纯度高、环境友好等优点。
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| 关 键 词： | 微波 N-苯基吡咯烷 苯胺 1 4-丁二醇二甲磺酸酯 精细化工中间体 |
Microwave-assisted Synthetic Technology of N-Phenylpyrrolidine |
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| LIANG Wu,LI Hong-bo,LIU Lang,CHEN Kai,WU Yi,WANG Long-fei.Microwave-assisted Synthetic Technology of N-Phenylpyrrolidine[J].Fine Chemicals,2011,28(2):188-190. |
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| Authors: | LIANG Wu LI Hong-bo LIU Lang CHEN Kai WU Yi WANG Long-fei |
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| Affiliation: | LIANG Wu,LI Hong-bo,LIU Lang,CHEN Kai,WU Yi,WANG Long-fei(School of Material Science and Engineering,Southwest University of Science and Technology,Mianyang 621010,Sichuan,China) |
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| Abstract: | N-Phenylpyrrolidine was synthesized from aniline and 1,4-butanediol dimethanesulfonate by the microwave-assisted reaction in the presence of deacid reagent.Through the single factor and orthogonal experiments,various factors influencing the yield were investigated.The optimal reaction conditions were obtained as follows:n(aniline)∶ n(1,4-butanediol dimethanesulfonate)∶ n(potassium carbonate)=1∶ 1.3∶ 1.3,reaction time 60 min,microwave power 200 W,reaction temperature 100 ℃.The yield 78.6 % of N-phenylpyrrolidine can be achieved in water under this condition.The optimal process conditions have the advantages of rapid reaction,mild conditions,simple operation,high product purity,and environment-friendliness. |
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| Keywords: | microwave N-phenylpyrrolidine aniline 1 4-butanediol dimethanesulfonate fine chemical intermediates |
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