| 邻三氟甲基苯胺的合成 |
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| 引用本文： | 刘海辉,杜晓华,陈静华,徐振元.邻三氟甲基苯胺的合成[J].农药,2005,44(10):464-465,470. |
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| 作者姓名： | 刘海辉 杜晓华 陈静华 徐振元 |
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| 作者单位： | 1. 浙江工业大学催化加氢研究中心、绿色化学合成技术国家重点实验室培育基地,杭州,310014
2. 浙江省东阳巍华化工有限公司,东阳,322109 |
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| 摘 要： | 以邻甲基苯胺为起始原料,先与双（三氯甲基）碳酸酯反应制得邻甲基苯基异氰酸酯,然后在过氧化物催化下侧链氯化得邻三氯甲基苯基异氰酸酯,最后在无水氟化氢中同时进行氟化和溶解得邻三氟甲基苯胺,三步总收率为55.3%,产品纯度在99%以上.此路线原料易得、操作安全、分离简单、产品纯度高,是一条可行的工业化路线.
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| 关 键 词： | 邻三氟甲基苯胺 中间体 合成 |
| 文章编号： | 1006-0413（2005）10-464-03 |
| 收稿时间： | 2005-02-03 |
| 修稿时间： | 2005-02-032005-03-28 |
Synthesis of O-(Trifluoromethyl)aniline |
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| LIU Hai-Hui,DU Xiao-Hua,CHEN Jing-Hua,XU Zhen-Yuan.Synthesis of O-(Trifluoromethyl)aniline[J].Pesticides,2005,44(10):464-465,470. |
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| Authors: | LIU Hai-Hui DU Xiao-Hua CHEN Jing-Hua XU Zhen-Yuan |
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| Affiliation: | 1.Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China; 2.Zhejiang Weihua Chemical Co., Ltd, Dongyang 322109, China |
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| Abstract: | An operationally safe and separately simple process was described for the preparation of o-(trifluoromethyl)aniline. Firstly, o-Toluidine as the starting material reacted with bis(trichloromethyl)carbonate to give o-tolylisocyanate.Secondly, o-tolylisocyanate was chlorinated in the presence of a peroxide to give o-(trichloromethyl)phenyl isocyanate.Finally, o-(trichloromethyl)phenyl isocyanate was fluorinated and solvolyzed in anhydrous hydrogen fluoride in one pot to yield thetitled compound o-(trifluoromethyl)aniline. The total yield was 55.3% and the purity of the product was above 99%. |
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| Keywords: | o-(trifluoromethyl)aniline intermediate preparation |
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