用于骨再生的铷改性生物活性玻璃陶瓷

为了研究铷(Rb)元素对CaO-SiO2-Na2O-B2O3-MgO-ZnO-P2O5系生物玻璃陶瓷的相组成、显微结构、力学性能和细胞响应的影响,设计加铷和不加铷的玻璃陶瓷成分.结果表明,在不含Rb的生物玻璃陶瓷基体中形成羟基磷灰石(HA)和Mg-白磷钙矿(Ca18Mg2H2(PO4)14)晶相;而添加Rb后,仅检测到...

Rubidium-modified bioactive glass-ceramics with hydroxyapatite crystals for bone regeneration

In order to study the influence of rubidium (Rb) addition on the phase composition, microstructure, mechanical properties and cell response of bioactive glass-ceramics, CaO–SiO₂–Na₂O–B₂O₃–MgO–ZnO–P₂O₅ glass system was designed with and without addition of Rb. The results show that hydroxyapatite (HA) and Mg–whitelockite (Ca₁₈Mg₂H₂(PO₄)₁₄) crystalline phases are formed in the glass matrix without Rb. After the addition of Rb, only HA phase is detected. The grain size of the crystals in the glass-ceramics is larger with the addition of Rb than that of samples without Rb. Rb addition can improve the bending strength of glass-ceramics. The cultivation of human bone marrow mesenchymal stem cells (hBMSCs) on Rb-containing glass-ceramics demonstrates enhanced cell adhesion, proliferation and ALP activity. In conclusion, Rb-modified glass-ceramics exhibit good mechanical property, excellent bioactivity and biocompatibility, which have potential for bone regeneration application.