酸性氨基酸二甲酯盐酸盐的合成工艺研究

采用氯化亚砜法,以两种酸性氨基酸、无水甲醇、氯化亚砜为原料酯化合成L-天冬氨酸二甲酯盐酸盐和L-谷氨酸二甲酯盐酸盐,讨论了加样顺序,反应时间tA,反应温度TA,反应时间tB和氨基酸与氯化亚砜的摩尔比对反应产率的影响,优化了两种氨基酸二甲酯盐酸盐的重结晶条件,确定了两种氨基酸二甲酯盐酸盐的最佳合成条件及最优重结晶方案。

Study on the Synthesis of Acidic Amino Acid Dimethyl Ester Hydrochlorides

L- Aspartie acid dimethyl ester hydrochloride and L -glutamic acid dimethyl ester hydrochloride were synthesized by esterifying processes, with anhydrous methanol, thionyl chloride and two acidic amino acids as raw materials. The factors affecting the yield, such as the order of adding the samples, the reaction time tA, the reaction temperature TA, the reaction time tB and the mole ratio of amino acid to SOCl2, were discussed. The reerystallization programs were also optimized. To obtain the highest yield of two acidic amino acid dimethyl ester hydrochlorides, the optimum operation conditions and the optimal scheme of recrystallization were determined.