苯基-2-胺基吡啶衍生物的合成

研究了一条新的制备苯基-2-胺基吡啶衍生物的方法。以1,2,4-三氯苯为起始原料,经过6步得到目标产物,并经过1HNMR和Ms对其进行了结构表征。反应过程包括Wittig反应、Staudinger反应、杂Wittig反应、分子内的电环化反应和1,3-质子转移等,并提出了合理的反应机理。该方法对难以通过偶联方式来制备的苯基-2-胺基吡啶类化合物提供了新的思路。

The Synthesis of Phenyl-2-amino Pyridines Derivatives

A new route of phenyl -2 -amino pyridine derivatives was presented.The desired compound was synthesized through 6 steps which used 1,2,4-trichlorobenzene as starting material and was characterized by 1 H NMR spectra and Ms.Those steps involved Wittig reaction , Staudinger reaction , aza -Wittig reaction , electrocyclic ring -closure of intramolecular and 1,3 -proton shift, ect.A reasonable reaction mechanism was proposed.The method provided a new way of phenyl -2-amino pyridine derivatives which ware was very difficult to synthesize by coupling.