| 水杨酸甲酯的合成工艺研究 |
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| 引用本文： | 朱铭,;袁旭宏,;叶余原,;黄海明,;陈红,;尤玉静,;熊双喜.水杨酸甲酯的合成工艺研究[J].当代化工,2014(7):1158-1160. |
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| 作者姓名： | 朱铭 ;袁旭宏 ;叶余原 ;黄海明 ;陈红 ;尤玉静 ;熊双喜 |
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| 作者单位： | [1]台州学院医药化工学院,浙江台州318000; [2]台州职业技术学院生化系,浙江台州318000 |
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| 基金项目： | 国家青年科学基金,项目号：21207095. |
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| 摘 要： | 通过水杨酸和甲醇为原料,分别在浓硫酸和硫酸氢钾催化作用下合成了水杨酸甲酯。考察了酸醇摩尔比、反应时间及催化剂用量对酯收率的影响。结果表明,使用硫酸氢钾做催化剂,n(水杨酸):n(甲醇)摩尔比=1:5,反应5 h,所获得的水杨酸甲酯的收率为最好,平均收率可以到达70%。
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| 关 键 词： | 酯化反应 水杨酸甲酯 反应条件 摩尔比 硫酸氢钾 |
Study on Synthesis of Methyl Salicylate |
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| Affiliation: | ZHU Ming, YUAN Xu-hong, YE Yu-yuan, HUANG Hai-ming, CHEN Hong, YOU Yu-jing, XIONG Shuang-xi ( 1. Department of Pharmaceutical and Chemical Engineering, Taizhou College, Zhejiang Taizhou 318000, China; 2. Yaizhou Vocational ＆ Technical College, Zhejiang Taizhou 318000, China ) |
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| Abstract: | Using salicylic acid and methanol as raw materials, methyl salicylate was respectively synthesized in concentrated sulfuric acid or potassium hydrogen sulfate. Effect of mole ratio of acid to alcohol, reaction time and catalyst dosage on yield of the ester was investigated. The results show that ,using potassium bisulfate as catalyst, n （salicylic acid）： n （methanol） = 1：5, reaction time 5 h, the highest yield of methyl salicylate can be obtained, average yield can reach to 70%. |
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| Keywords: | Esterification Methyl salicylate Condition Mole ratio Potassium bisulfate |
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