Changes in in vivo metabolism of bile acids in rat after treatment with phenobarbital |
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| Authors: | Tomas Cronholm Kurt Einarsson Jan-Åke Gustafsson |
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| Affiliation: | (1) Department of Chemistry, Karolinska Institutet, Serafimerlasarettet, Stockholm, Sweden;(2) Department of Medicine, Karolinska Institutet, Serafimerlasarettet, Stockholm, Sweden;(3) Department of Chemistry and Department of Germfree Research, Karolinska Institutet, Serafimerlasarettet, Stockholm, Sweden |
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| Abstract: | The influence of phenobarbital on pool size and turnover of bile acids in rats have been investigated by administration of
24-14C] cholic acid and tritium labeled chenodeoxycholic acid. Phenobarbital treated rats had a smaller cholic acid pool compared
to control rats (6.08±2.09 mg and 23.60±7.66 mg, respectively). The pool size of chenodeoxycholic acid, plus its metabolites
(α- and β-muricholic acids), was of the same magnitude in the two groups of animals. Also the daily production of cholic acid
was decreased in phenobarbital treated rats compared to control rats (2.12±0.46 mg and 7.24±1.66 mg, respectively). No significant
difference was observed between the synthesis of chenodeoxycholic acid in the two groups of animals. |
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