合成叔丁基苯酚的固体酸催化反应过程研究

在固定床反应器内进行了以固体酸催化合成叔丁基苯酚实验，结果表明，制备的催化剂活性稳定性优于HY分子筛。在反应压力6.0 MPa、反应温度260 ℃、n(苯酚)∶n(叔丁醇)=1∶3和质量空速4.4 h-1的较佳反应条件下进行苯酚与叔丁醇烷基化反应，苯酚转化率为78.3%，2-叔丁基苯酚选择性为10.3%，4-叔丁基苯酚选择性为63.5%，2,4-二叔丁基苯酚选择性为25.1%，催化剂活性稳定时间超过530 h。在反应压力6.0 MPa、反应温度240 ℃、n(苯酚)∶n(甲基叔丁基醚)=1∶3和质量空速1.3 h^-1条件下进行甲基叔丁基醚与苯酚烷基化反应，苯酚转化率为70.9%，2-叔丁基苯酚选择性为27.7%，4-叔丁基苯酚选择性为35.7%，2,4-二叔丁基苯酚选择性为29.7%。与叔丁醇相比，甲基叔丁基醚的苯酚烷基化活性和2,4-二叔丁基苯酚选择性均较高，但副产物较多。对于合成叔丁基苯酚，叔丁醇是较佳的烷基化试剂。

Catalytic reaction process for synthesis of tert-butyl-phenol over solid acid

Using the solid acid as the catalyst, tert-butyl-phenol （TBP） was synthesized in a fixed-bed reactor. The experimental results showed that the acitivity stability of self-made catalyst was better than that of HY molecular sieve. Phenol conversion of 78. 3% , and the selectivity to 2-tert-butyl-phenol （ 2 -TBP） of 10.3 %, 4 -tert-butyl-phenol （4-TBP） of 63.5 % and 2,4 -di-tert-butyl-phenol （2,4-DTBP） of 25.1% were attained under the optimum condition of pressure 6.0 MPa, temperature 260 ℃, phenol/tert- butanol molar ratio 1：3 and the weight hourly space velocity（WHSV） 4.4 h-1. The stable time of the cat- alyst with higher activity was more than 530 h. Phenol conversion and the selectivity to 2-TBP,4-TBP and 2,4-DTBP reached 70.9% ,27.7% ,35.7% and 29.7% ,respectively under the reaction condition as fol- lows：pressure 6.0 MPa, temperature 240 ℃, phenol/methyl tert-butyl ether（MTBE） molar ratio of 1：3 and WHSV 1.3 h - 1, Compared with ten-butanol as the alkylating reagent, the activity of phenol alkylation with MTBE and the selectivity to 2,4-DTBP were both higher,but the by-products were more. Therefore, tert-butanol was an better alkylating reagent for synthesis of tert-hutyl-phenol.